This Ion GeneStudio S5 Series is a used laboratory sequencing instrument — a semiconductor-based next-generation sequencer, sometimes referred to simply as an NGS system — designed for targeted DNA and RNA sequencing workflows in clinical research and scientific research settings. Manufactured by Thermo Fisher Scientific, a globally recognised life sciences company known for producing analytical instruments, reagents, and laboratory equipment across genomics, proteomics, and diagnostics, the GeneStudio S5 Series represents the company's semiconductor sequencing platform built for labs requiring flexible, scalable throughput without the complexity of larger sequencing systems. This unit is located in Poland and is offered at $72,000.
The system operates on Ion Semiconductor Sequencing technology and is compatible with the Ion 5 Series chip family, spanning the Ion 510, 520, 530, and 540 chips. This chip selection allows the instrument to scale output from approximately 2 million to 80 million reads per run, giving laboratories the flexibility to match throughput to the specific demands of a given application — whether that is small targeted gene panels, microbial genome sequencing, exome sequencing, or transcriptomics.
Reagent handling is cartridge-based, using a plug-and-play format intended to reduce setup time and operator complexity. When paired with the Ion Chef System for automated library and template preparation, total hands-on time can be as low as 45 minutes, with a complete workflow from DNA library to analysable data achievable within 24 hours. A full sequencing run and primary analysis can be completed within a matter of hours.
The GeneStudio S5 is the entry-level instrument in a three-tier family that also includes the Ion GeneStudio S5 Plus and the Ion GeneStudio S5 Prime. All three instruments share the same foundational semiconductor sequencing technology and fluidic architecture; the principal distinction between them lies in on-sequencer analysis time. The S5 is optimised for laboratories focused on smaller panels and lower-to-moderate throughput requirements.
The system supports low-input samples, accepting as little as 1 ng of input DNA or RNA. This makes it suitable for challenging sample types including formalin-fixed paraffin-embedded (FFPE) tissue, fine needle aspirate retrospective samples, and cell-free DNA (cfDNA) extracted from blood — sample categories that can be problematic on other next-generation sequencing platforms.
Software support is provided through Torrent Suite Software, which comes pre-installed on the Torrent Server and handles run planning, monitoring, tracking, and primary analysis. Variant integration, annotation, and interpretation are handled by Ion Reporter Software, available via the Thermo Fisher Cloud or as a local installation depending on laboratory preference. The user interface is described as straightforward, and the system is designed for single-day installation.
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